Los Angeles takes an eight-game winning streak against AFC teams into Sunday night's game at Denver, while the Broncos aim for a 10th consecutive win over NFC opponents. The Rams' last AFC loss was 23-15 to Miami at home in 2024.
The Rams went 5-0 against the AFC in 2025 and 17-8 against the conference in the 17-game era. Since Sean McVay took over in 2017, they are 29-13 in interconference games, including their Super Bowl win over Cincinnati.
Denver has lost five straight games against the Rams and has not beaten Los Angeles since 2002. Broncos quarterback Bo Nix has lost once to an NFC opponent: Seattle in his NFL debut.
