A nine-month randomized trial found that vitamin D3 (at least 1,000 IU daily) was associated with an 18.6% rise in adiponectin and a 32.4% fall in resistin among vitamin D-deficient women ages 50–65; the changes were significant versus placebo.
Adiponectin and resistin are adipokines—signaling proteins produced by fat tissue, not reproductive hormones. The supplement group’s 25-hydroxyvitamin D, the main blood marker used to assess vitamin D status, increased 45.4%; the placebo group’s level decreased 18.5%.
The reported trial findings concern changes in adipokine levels. The article does not report direct evidence of improved blood sugar, body composition or cardiovascular health.
