The Los Angeles Rams lost 30-26 to Denver after leading 16-0, falling to 1-2 despite outgaining the Broncos 482-257. Terrance Ferguson re-aggravated an ankle injury in the first quarter and did not return; cornerback Jaylen Watson injured his shoulder.
Kyren Williams rushed for 88 yards on 15 carries and caught six passes for 70 yards. Davante Adams had seven receptions for 137 yards. Matthew Stafford completed 30 of 55 passes for 390 yards, two touchdowns and two interceptions; Talanoa Hufanga returned one interception for a Denver touchdown.
The Rams were penalized 13 times for 91 yards, compared with Denver's five flags for 38 yards; the Broncos gained four first downs on penalties. In the second half, Kobie Turner forced a Bo Nix interception that Josh Wallace caught, helping Los Angeles regain the lead before Denver went ahead again.
